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KMID : 1188320090030030174
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Gut and Liver
2009 Volume.3 No. 3 p.174 ~ p.179
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The Relationship between Small-Intestinal Bacterial Overgrowth and Intestinal Permeability in Patients with Irritable Bowel Syndrome
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Park Jung-Ho
Park Dong-Il
Kim Hong-Joo
Cho Yong-Kyun
Sohn Chong-Il
Jeon Woo-Kyu
Kim Byung-Ik
Won Kyoung-Hee
Park Soon-Min
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Abstract
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Background/Aims: Small-intestinal bacterial overgrowth (SIBO) is a frequent finding in patients with irritable bowel syndrome (IBS). Many patients with IBS also have abnormal intestinal permeability, which is probably due to low-grade inflammation in the intestinal mucosa. Our aim was to verify the relationship between SIBO and small-intestinal permeability in IBS patients.
Methods: A cohort of 38 IBS patients (20 women and 18 men; age range 16-70 years; mean age 40.2 years) with symptoms that fulfilled Rome-II criteria, and 12 healthy controls (5 women and 7 men; age range 25-52 years; mean age: 37.8 years) were recruited. All subjects underwent lactulose breath tests (LBTs) and intestinal permeability tests using the polyethylene glycol (PEG) 3350/400 retrieval ratio.
Results: A positive LBT was found in 18.4% (7/38) of patients with IBS and 8.3% (1/12) of control subjects. Intestinal permeability was significantly increased in patients with IBS compared with the normal controls (0.82±0.09 vs 0.41±0.05 [mean±SD], respectively; p＜0.05). However, the intestinal permeability did not differ significantly between IBS patients with a positive LBT and those with a negative LBT (0.90±0.13 and 0.80±0.11, respectively; p＞0.05).
Conclusions: Intestinal permeability was increased in patients with IBS, but this finding did not correlated with the occurrence of SIBO.
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KEYWORD
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Small intestinal bacterial overgrowth, Intestinal permeability, Irritable bowel syndrome
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